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A fine balance among key biophysical factors is required for recovery of bipolar mitotic spindle from monopolar and multipolar abnormalities

During mitosis, equal partitioning of chromosomes into two daughter cells requires assembly of a bipolar mitotic spindle. Because the spindle poles are each organized by a centrosome in animal cells, centrosome defects can lead to monopolar or multipolar spindles. However, the cell can effectively r...

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Detalles Bibliográficos
Autores principales: Li, Xiaochu, Bloomfield, Mathew, Bridgeland, Alexandra, Cimini, Daniela, Chen, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398891/
https://www.ncbi.nlm.nih.gov/pubmed/37342878
http://dx.doi.org/10.1091/mbc.E22-10-0485