Matrix obstructions cause multiscale disruption in collective epithelial migration by suppressing leader cell function

During disease and development, physical changes in extracellular matrix cause jamming, unjamming, and scattering in epithelial migration. However, whether disruptions in matrix topology alter collective cell migration speed and cell–cell coordination remains unclear. We microfabricated substrates w...

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Detalles Bibliográficos
Autores principales: Lee, Ye Lim, Mathur, Jairaj, Walter, Christopher, Zmuda, Hannah, Pathak, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2023
Materias:
Special Issue on Forces On And Within Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398892/
https://www.ncbi.nlm.nih.gov/pubmed/37379202
http://dx.doi.org/10.1091/mbc.E22-06-0226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398892/
https://www.ncbi.nlm.nih.gov/pubmed/37379202
http://dx.doi.org/10.1091/mbc.E22-06-0226

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