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Hippocampus of the APP(NL–G–F) mouse model of Alzheimer’s disease exhibits region-specific tissue softening concomitant with elevated astrogliosis

Widespread neurodegeneration, enlargement of cerebral ventricles, and atrophy of cortical and hippocampal brain structures are classic hallmarks of Alzheimer’s disease (AD). Prominent macroscopic disturbances to the cytoarchitecture of the AD brain occur alongside changes in the mechanical propertie...

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Detalles Bibliográficos
Autores principales: Hall, Chloe M., Lasli, Soufian, Serwinski, Bianca, Djordjevic, Boris, Sheridan, Graham K., Moeendarbary, Emad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398960/
https://www.ncbi.nlm.nih.gov/pubmed/37547743
http://dx.doi.org/10.3389/fnagi.2023.1212212