Optimized allotopic expression of mitochondrial ND6 transgene restored complex I and apoptosis deficiencies caused by LHON-linked ND6 14484T > C mutation

BACKGROUND: Leber’s hereditary optic neuropathy (LHON) is a maternally inherited eye disease due to mutations in mitochondrial DNA. However, there is no effective treatment for this disease. LHON-linked ND6 14484T > C (p.M64V) mutation caused complex I deficiency, diminished ATP production, incre...

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Detalles Bibliográficos
Autores principales: Wang, Jing, Ji, Yanchun, Ai, Cheng, Chen, Jia-Rong, Gan, Dingyi, Zhang, Juanjuan, Mo, Jun Q., Guan, Min-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399063/
https://www.ncbi.nlm.nih.gov/pubmed/37537557
http://dx.doi.org/10.1186/s12929-023-00951-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399063/
https://www.ncbi.nlm.nih.gov/pubmed/37537557
http://dx.doi.org/10.1186/s12929-023-00951-1

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