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Optimized allotopic expression of mitochondrial ND6 transgene restored complex I and apoptosis deficiencies caused by LHON-linked ND6 14484T > C mutation

BACKGROUND: Leber’s hereditary optic neuropathy (LHON) is a maternally inherited eye disease due to mutations in mitochondrial DNA. However, there is no effective treatment for this disease. LHON-linked ND6 14484T > C (p.M64V) mutation caused complex I deficiency, diminished ATP production, incre...

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Detalles Bibliográficos
Autores principales:	Wang, Jing, Ji, Yanchun, Ai, Cheng, Chen, Jia-Rong, Gan, Dingyi, Zhang, Juanjuan, Mo, Jun Q., Guan, Min-Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399063/ https://www.ncbi.nlm.nih.gov/pubmed/37537557 http://dx.doi.org/10.1186/s12929-023-00951-1

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