Cargando…

Predictive Modeling of HMG-CoA Reductase Inhibitory Activity and Design of New HMG-CoA Reductase Inhibitors

[Image: see text] As blood cholesterol increases, it accumulates in the intima of blood vessels, elevating the risk of atherosclerosis and coronary artery disease. Drugs that inhibit enzymes essential for cholesterol synthesis are effective in improving blood cholesterol levels. Statins are used to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Samizo, Shigeyoshi, Kaneko, Hiromasa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399166/ https://www.ncbi.nlm.nih.gov/pubmed/37546661 http://dx.doi.org/10.1021/acsomega.3c02567

Ejemplares similares

Pleiotropic effects of the HMG-CoA reductase inhibitors
por: Mihos, Christos G, et al.
Publicado: (2011)

Positive pleiotropic effects of HMG-CoA reductase inhibitor on vitiligo
por: Noël, Martin, et al.
Publicado: (2004)

The role of HMG-CoA reductase inhibition in endothelial dysfunction and inflammation
por: Gelosa, Paolo, et al.
Publicado: (2007)

Transcription of the three HMG-CoA reductase genes of Mucor circinelloides
por: Nagy, Gábor, et al.
Publicado: (2014)

Functional Implications of HMG-CoA Reductase Inhibition on Glucose Metabolism
por: Han, Ki Hoon
Publicado: (2018)

Chronic Onset Form of Anti-HMG-CoA Reductase Myopathy
por: Lorenzo-Villalba, Noel, et al.
Publicado: (2021)

Eupatilin Alleviates Hyperlipidemia in Mice by Inhibiting HMG-CoA Reductase
por: Kim, Kyung-Joo, et al.
Publicado: (2023)

Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor
por: Bose, Sucharita, et al.
Publicado: (2023)

Are Point Mutations in HMG-CoA Reductases (Hmg1 and Hmg2) a Step towards Azole Resistance in Aspergillus fumigatus?
por: Gonzalez-Jimenez, Irene, et al.
Publicado: (2021)

Role of HMG-CoA reductase inhibitors with curative radiotherapy in men with prostate cancer
por: Solanki, Abhishek A, et al.
Publicado: (2011)

The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases
por: Friesen, Jon A, et al.
Publicado: (2004)

Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase
por: Würtz, Peter, et al.
Publicado: (2016)

The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase
por: Schumacher, Marc M, et al.
Publicado: (2015)

Pilot Algorithm Designed to Help Early Detection of HMG-CoA Reductase Inhibitor-Induced Hepatotoxicity
por: Hong, Joo Young, et al.
Publicado: (2017)

HMG CoA reductase inhibitors (statins) to treat Epstein–Barr virus-driven lymphoma
por: Cohen, J I
Publicado: (2005)

Association between Use of HMG CoA Reductase Inhibitors and Mortality in HIV-Infected Patients
por: Moore, Richard D., et al.
Publicado: (2011)

Direct free radical scavenging effects of water-soluble HMG-CoA reductase inhibitors
por: Umeda, Ryohei, et al.
Publicado: (2019)

Development of Clinical Data Mart of HMG-CoA Reductase Inhibitor for Varied Clinical Research
por: Kim, Hun-Sung, et al.
Publicado: (2017)

Use of HMG-CoA Reductase Inhibitors in the HIV Population: Implications for Individualized Treatment Selection
por: Advani, Ashish, et al.
Publicado: (2014)

HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis
por: Palmer, Suetonia C., et al.
Publicado: (2015)

HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis
por: Palmer, Suetonia C., et al.
Publicado: (2014)

Lepidopteran HMG-CoA reductase is a potential selective target for pest control
por: Li, Yuan-mei, et al.
Publicado: (2017)

Degradation of HMG-CoA reductase-induced membranes in the fission yeast, Schizosaccharomyces pombe
Publicado: (1995)

HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival
por: Lacher, Sonja M, et al.
Publicado: (2017)

An Atomic-Level Perspective of HMG-CoA-Reductase: The Target Enzyme to Treat Hypercholesterolemia
por: Gesto, Diana S., et al.
Publicado: (2020)

Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition
por: Kettunen, Johannes, et al.
Publicado: (2019)

Modulation of Dendritic Cell Immunobiology via Inhibition of 3-Hydroxy-3-Methylglutaryl-CoA (HMG-CoA) Reductase
por: Leuenberger, Tina, et al.
Publicado: (2014)

Benefit–risk assessment of HMG-CoA reductase inhibitors (statins): a discrete choice experiment
por: Wanishayakorn, Tanatape, et al.
Publicado: (2016)

Influence of extraction methods of bay leaves (Syzygium polyanthum) on antioxidant and HMG-CoA Reductase inhibitory activity
por: Hartanti, Lanny, et al.
Publicado: (2019)

Structural and functional characterization of HMG-COA reductase from Artemisia annua
por: Kiran, Usha, et al.
Publicado: (2010)

Cholesterol, C-Reactive Protein, and Periodontitis: HMG-CoA-Reductase Inhibitors (Statins) as Effect Modifiers
por: Meisel, Peter, et al.
Publicado: (2011)

Attenuation of pulmonary hypertension secondary to left ventricular dysfunction in the rat by HMG-CoA reductase inhibitor
por: Chen, K.-H., et al.
Publicado: (2011)

Potential natural inhibitors of xanthine oxidase and HMG-CoA reductase in cholesterol regulation: in silico analysis
por: Marahatha, Rishab, et al.
Publicado: (2021)

Statins: HMG-CoA Reductase Inhibitors as Potential Anticancer Agents against Malignant Neoplasms in Women
por: Markowska, Anna, et al.
Publicado: (2020)

HMG-CoA Reductase Inhibitor, Simvastatin Is Effective in Decreasing Degree of Myocarditis by Inhibiting Metalloproteinases Activation
por: Skrzypiec-Spring, Monika, et al.
Publicado: (2021)

Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast
Publicado: (1994)

Prognostic impact of tumour-specific HMG-CoA reductase expression in primary breast cancer
por: Borgquist, Signe, et al.
Publicado: (2008)

Antihyperlipidemic Activity of Aloe succotrina in Rats: Possibly Mediated by Inhibition of HMG-CoA Reductase
por: Dhingra, Dinesh, et al.
Publicado: (2014)

Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system
por: Tsai, Yien Che, et al.
Publicado: (2012)

Correction: Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition
por: Kettunen, Johannes, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_l3m7pcm66116e0krb3sb1q8fl8