Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range

[Image: see text] The biological and pathological functions of cathepsin B occur in acidic lysosomes and at the neutral pH of cytosol, nuclei, and extracellular locations. Importantly, cathepsin B displays different substrate cleavage properties at acidic pH compared to neutral pH conditions. It is,...

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Detalles Bibliográficos
Autores principales: Yoon, Michael C., Phan, Von, Podvin, Sonia, Mosier, Charles, O’Donoghue, Anthony J., Hook, Vivian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399199/
https://www.ncbi.nlm.nih.gov/pubmed/37459182
http://dx.doi.org/10.1021/acs.biochem.3c00139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399199/
https://www.ncbi.nlm.nih.gov/pubmed/37459182
http://dx.doi.org/10.1021/acs.biochem.3c00139

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