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A bacterial enzyme may correct 2-HG accumulation in human cancers
A significant proportion of lower-grade glioma as well as many other types of human cancers are associated with neomorphic mutations in IDH1/2 genes (mIDH1/2). These mutations lead to an aberrant accumulation of 2-hydroxyglutarate (2-HG). Interestingly, even cancers without mIDH1/2 can exhibit incre...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399246/ https://www.ncbi.nlm.nih.gov/pubmed/37546420 http://dx.doi.org/10.3389/fonc.2023.1235191 |