Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells

Oxidative stress has been implicated in the pathogenesis of age-related macular degeneration, the leading cause of blindness in older adults, with retinal pigment epithelium (RPE) cells playing a key role. To better understand the cytotoxic mechanisms underlying oxidative stress, we used cell cultur...

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Detalles Bibliográficos
Autores principales: Zhang, Kevin R., Jankowski, Connor S. R., Marshall, Rayna, Nair, Rohini, Más Gómez, Néstor, Alnemri, Ahab, Liu, Yingrui, Erler, Elizabeth, Ferrante, Julia, Song, Ying, Bell, Brent A., Baumann, Bailey H., Sterling, Jacob, Anderson, Brandon, Foshe, Sierra, Roof, Jennifer, Fazelinia, Hossein, Spruce, Lynn A., Chuang, Jen-Zen, Sung, Ching-Hwa, Dhingra, Anuradha, Boesze-Battaglia, Kathleen, Chavali, Venkata R. M., Rabinowitz, Joshua D., Mitchell, Claire H., Dunaief, Joshua L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399446/
https://www.ncbi.nlm.nih.gov/pubmed/37401371
http://dx.doi.org/10.1242/dmm.050066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399446/
https://www.ncbi.nlm.nih.gov/pubmed/37401371
http://dx.doi.org/10.1242/dmm.050066

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