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Proliferating cell nuclear antigen inhibitors block distinct stages of herpes simplex virus infection

Proliferating cell nuclear antigen (PCNA) forms a homotrimer that encircles replicating DNA and is bound by DNA polymerases to add processivity to cellular DNA synthesis. In addition, PCNA acts as a scaffold to recruit DNA repair and chromatin remodeling proteins to replicating DNA via its interdoma...

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Detalles Bibliográficos
Autores principales: Packard, Jessica E., Williams, Maya R., Fromuth, Daniel P., Dembowski, Jill A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399828/
https://www.ncbi.nlm.nih.gov/pubmed/37486931
http://dx.doi.org/10.1371/journal.ppat.1011539