Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics

Central metabolic pathways control virulence and antibiotic resistance, and constitute potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose phosphate pathway (PPP) remains largely unexplored. Mutation of the 6-phosphogluconolactonase gene pgl, which encodes the...

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Detalles Bibliográficos
Autores principales: Zeden, Merve S., Gallagher, Laura A., Bueno, Emilio, Nolan, Aaron C., Ahn, Jongsam, Shinde, Dhananjay, Razvi, Fareha, Sladek, Margaret, Burke, Órla, O’Neill, Eoghan, Fey, Paul D., Cava, Felipe, Thomas, Vinai C., O’Gara, James P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399904/
https://www.ncbi.nlm.nih.gov/pubmed/37486930
http://dx.doi.org/10.1371/journal.ppat.1011536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399904/
https://www.ncbi.nlm.nih.gov/pubmed/37486930
http://dx.doi.org/10.1371/journal.ppat.1011536

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