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Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics
Central metabolic pathways control virulence and antibiotic resistance, and constitute potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose phosphate pathway (PPP) remains largely unexplored. Mutation of the 6-phosphogluconolactonase gene pgl, which encodes the...
Autores principales: | Zeden, Merve S., Gallagher, Laura A., Bueno, Emilio, Nolan, Aaron C., Ahn, Jongsam, Shinde, Dhananjay, Razvi, Fareha, Sladek, Margaret, Burke, Órla, O’Neill, Eoghan, Fey, Paul D., Cava, Felipe, Thomas, Vinai C., O’Gara, James P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399904/ https://www.ncbi.nlm.nih.gov/pubmed/37486930 http://dx.doi.org/10.1371/journal.ppat.1011536 |
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