Optogenetic control of Wnt signaling models cell-intrinsic embryogenic patterning using 2D human pluripotent stem cell culture

In embryonic stem cell (ESC) models for early development, spatially and temporally varying patterns of signaling and cell types emerge spontaneously. However, mechanistic insight into this dynamic self-organization is limited by a lack of methods for spatiotemporal control of signaling, and the rel...

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Detalles Bibliográficos
Autores principales: Repina, Nicole A., Johnson, Hunter J., Bao, Xiaoping, Zimmermann, Joshua A., Joy, David A., Bi, Shirley Z., Kane, Ravi S., Schaffer, David V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Human Development
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399980/
https://www.ncbi.nlm.nih.gov/pubmed/37401411
http://dx.doi.org/10.1242/dev.201386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399980/
https://www.ncbi.nlm.nih.gov/pubmed/37401411
http://dx.doi.org/10.1242/dev.201386

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