VCP promotes tTAF-target gene expression and spermatocyte differentiation by downregulating mono-ubiquitylated H2A

Valosin-containing protein (VCP) binds and extracts ubiquitylated cargo to regulate protein homeostasis. VCP has been studied primarily in aging and disease contexts, but it also affects germline development. However, the precise molecular functions of VCP in the germline, particularly in males, are...

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Detalles Bibliográficos
Autores principales: Butsch, Tyler J., Dubuisson, Olga, Johnson, Alyssa E., Bohnert, K. Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399981/
https://www.ncbi.nlm.nih.gov/pubmed/37401420
http://dx.doi.org/10.1242/dev.201557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399981/
https://www.ncbi.nlm.nih.gov/pubmed/37401420
http://dx.doi.org/10.1242/dev.201557

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