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Phylogenetic Reconstruction and Functional Characterization of the Ancestral Nef Protein of Primate Lentiviruses
Nef is an accessory protein unique to the primate HIV-1, HIV-2, and SIV lentiviruses. During infection, Nef functions by interacting with multiple host proteins within infected cells to evade the immune response and enhance virion infectivity. Notably, Nef can counter immune regulators such as CD4 a...
Autores principales: | Olabode, Abayomi S, Mumby, Mitchell J, Wild, Tristan A, Muñoz-Baena, Laura, Dikeakos, Jimmy D, Poon, Art F Y |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400143/ https://www.ncbi.nlm.nih.gov/pubmed/37463439 http://dx.doi.org/10.1093/molbev/msad164 |
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