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Surface plasmon resonance and microscale thermophoresis approaches for determining the affinity of perforin for calcium ions

Perforin is a pore-forming protein that plays a crucial role in the immune system by clearing virus-infected or tumor cells. It is released from cytotoxic granules of immune cells and forms pores in targeted lipid membranes to deliver apoptosis-inducing granzymes. It is a very cytotoxic protein and...

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Detalles Bibliográficos
Autores principales: Naneh, Omar, Kozorog, Mirijam, Merzel, Franci, Gilbert, Robert, Anderluh, Gregor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400287/
https://www.ncbi.nlm.nih.gov/pubmed/37545534
http://dx.doi.org/10.3389/fimmu.2023.1181020