NPM1 mutation reprograms leukemic transcription network via reshaping TAD topology

C-terminal mutation of Nucleophosmin 1 (NPM1(C+)) was thought to be a primary driving event in acute myeloid leukemia (AML) that reprograms leukemic-associated transcription programs to transform hematopoietic stem and progenitor cells (HSPCs). However, molecular mechanisms underlying NPM1(C+)-drive...

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Detalles Bibliográficos
Autores principales: Lai, Qian, Hamamoto, Karina, Luo, Huacheng, Zaroogian, Zachary, Zhou, Caixian, Lesperance, Julia, Zha, Jie, Qiu, Yi, Guryanova, Olga A., Huang, Suming, Xu, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400418/
https://www.ncbi.nlm.nih.gov/pubmed/37365294
http://dx.doi.org/10.1038/s41375-023-01942-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400418/
https://www.ncbi.nlm.nih.gov/pubmed/37365294
http://dx.doi.org/10.1038/s41375-023-01942-9

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