The ribosomal protein S6 kinase alpha-1 (RPS6KA1) induces resistance to venetoclax/azacitidine in acute myeloid leukemia

Venetoclax/azacitidine combination therapy is effective in acute myeloid leukemia (AML) and tolerable for older, multimorbid patients. Despite promising response rates, many patients do not achieve sustained remission or are upfront refractory. Identification of resistance mechanisms and additional...

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Detalles Bibliográficos
Autores principales: Weidenauer, Katharina, Schmidt, Christina, Rohde, Christian, Pauli, Cornelius, Blank, Maximilian F., Heid, Daniel, Waclawiczek, Alexander, Corbacioglu, Anika, Göllner, Stefanie, Lotze, Michelle, Vierbaum, Lisa, Renders, Simon, Krijgsveld, Jeroen, Raffel, Simon, Sauer, Tim, Trumpp, Andreas, Pabst, Caroline, Müller-Tidow, Carsten, Janssen, Maike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400424/
https://www.ncbi.nlm.nih.gov/pubmed/37414921
http://dx.doi.org/10.1038/s41375-023-01951-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400424/
https://www.ncbi.nlm.nih.gov/pubmed/37414921
http://dx.doi.org/10.1038/s41375-023-01951-8

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