EP1 activation inhibits doxorubicin-cardiomyocyte ferroptosis via Nrf2

Chemotherapeutic agents, such as doxorubicin (DOX), may cause cardiomyopathy, even life-threatening arrhythmias in cancer patients. Ferroptosis-an iron-dependent oxidative form of programmed necrosis, plays a pivotal role in DOX-induced cardiomyopathy (DIC). Prostaglandins (PGs) are bioactive signal...

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Detalles Bibliográficos
Autores principales: Wang, Bei, Jin, Yuxuan, Liu, Jiao, Liu, Qian, Shen, Yujun, Zuo, Shengkai, Yu, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400469/
https://www.ncbi.nlm.nih.gov/pubmed/37531930
http://dx.doi.org/10.1016/j.redox.2023.102825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400469/
https://www.ncbi.nlm.nih.gov/pubmed/37531930
http://dx.doi.org/10.1016/j.redox.2023.102825

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