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A chlorzoxazone–folic acid combination improves cognitive affective decline in SCA2-58Q mice

Spinocerebellar ataxia type 2 (SCA2) is a polyglutamine disorder caused by a pathological expansion of CAG repeats in ATXN2 gene. SCA2 is accompanied by cerebellar degeneration and progressive motor decline. Cerebellar Purkinje cells (PCs) seem to be primarily affected in this disorder. The majority...

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Detalles Bibliográficos
Autores principales: Marinina, Ksenia S., Bezprozvanny, Ilya B., Egorova, Polina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400576/
https://www.ncbi.nlm.nih.gov/pubmed/37537226
http://dx.doi.org/10.1038/s41598-023-39331-y