Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction

Cholesteatoma, which potentially results from tympanic membrane retraction, is characterized by intractable local bone erosion and subsequent hearing loss and brain abscess formation. However, the pathophysiological mechanisms underlying bone destruction remain elusive. Here, we performed a single-c...

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Detalles Bibliográficos
Autores principales: Shimizu, Kotaro, Kikuta, Junichi, Ohta, Yumi, Uchida, Yutaka, Miyamoto, Yu, Morimoto, Akito, Yari, Shinya, Sato, Takashi, Kamakura, Takefumi, Oshima, Kazuo, Imai, Ryusuke, Liu, Yu-Chen, Okuzaki, Daisuke, Hara, Tetsuya, Motooka, Daisuke, Emoto, Noriaki, Inohara, Hidenori, Ishii, Masaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400591/
https://www.ncbi.nlm.nih.gov/pubmed/37537159
http://dx.doi.org/10.1038/s41467-023-40094-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400591/
https://www.ncbi.nlm.nih.gov/pubmed/37537159
http://dx.doi.org/10.1038/s41467-023-40094-3

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