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Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction
Cholesteatoma, which potentially results from tympanic membrane retraction, is characterized by intractable local bone erosion and subsequent hearing loss and brain abscess formation. However, the pathophysiological mechanisms underlying bone destruction remain elusive. Here, we performed a single-c...
Autores principales: | Shimizu, Kotaro, Kikuta, Junichi, Ohta, Yumi, Uchida, Yutaka, Miyamoto, Yu, Morimoto, Akito, Yari, Shinya, Sato, Takashi, Kamakura, Takefumi, Oshima, Kazuo, Imai, Ryusuke, Liu, Yu-Chen, Okuzaki, Daisuke, Hara, Tetsuya, Motooka, Daisuke, Emoto, Noriaki, Inohara, Hidenori, Ishii, Masaru |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400591/ https://www.ncbi.nlm.nih.gov/pubmed/37537159 http://dx.doi.org/10.1038/s41467-023-40094-3 |
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