Convergent synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonate approach

Phosphorodiamidate morpholino oligonucleotides (PMOs) are a promising type of antisense oligonucleotides, but their challenging synthesis makes them difficult to access. This research presents an efficient synthetic approach for PMOs using the H-phosphonate approach. The use of phosphonium-type cond...

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Detalles Bibliográficos
Autores principales: Tsurusaki, Taiki, Sato, Kazuki, Imai, Hiroki, Hirai, Kunihiro, Takahashi, Daisuke, Wada, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400599/
https://www.ncbi.nlm.nih.gov/pubmed/37537221
http://dx.doi.org/10.1038/s41598-023-38698-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400599/
https://www.ncbi.nlm.nih.gov/pubmed/37537221
http://dx.doi.org/10.1038/s41598-023-38698-2

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