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A neural-mechanistic hybrid approach improving the predictive power of genome-scale metabolic models

Constraint-based metabolic models have been used for decades to predict the phenotype of microorganisms in different environments. However, quantitative predictions are limited unless labor-intensive measurements of media uptake fluxes are performed. We show how hybrid neural-mechanistic models can...

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Detalles Bibliográficos
Autores principales: Faure, Léon, Mollet, Bastien, Liebermeister, Wolfram, Faulon, Jean-Loup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400647/
https://www.ncbi.nlm.nih.gov/pubmed/37537192
http://dx.doi.org/10.1038/s41467-023-40380-0