DNM2 levels normalization improves muscle phenotypes of a novel mouse model for moderate centronuclear myopathy

Dynamin 2 (DNM2) is a ubiquitously expressed GTPase regulating membrane trafficking and cytoskeleton dynamics. Heterozygous dominant mutations in DNM2 cause centronuclear myopathy (CNM), associated with muscle weakness and atrophy and histopathological hallmarks as fiber hypotrophy and organelles mi...

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Detalles Bibliográficos
Autores principales: de Carvalho Neves, Juliana, Moschovaki-Filippidou, Foteini, Böhm, Johann, Laporte, Jocelyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400865/
https://www.ncbi.nlm.nih.gov/pubmed/37547294
http://dx.doi.org/10.1016/j.omtn.2023.07.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400865/
https://www.ncbi.nlm.nih.gov/pubmed/37547294
http://dx.doi.org/10.1016/j.omtn.2023.07.003

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