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A conserved 3D pattern in a Streptococcus pyogenes M protein immunogen elicits M-type crossreactivity

Coiled coil–forming M proteins of the widespread and potentially deadly bacterial pathogen Streptococcus pyogenes (strep A) are immunodominant targets of opsonizing antibodies. However, antigenic sequence variability of M proteins into >220 M types, as defined by their hypervariable regions (HVRs...

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Detalles Bibliográficos
Autores principales:	Wang, Kuei-Chen, Kuliyev, Eziz, Nizet, Victor, Ghosh, Partho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400905/ https://www.ncbi.nlm.nih.gov/pubmed/37390991 http://dx.doi.org/10.1016/j.jbc.2023.104980

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