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Anabolic phenotype in cartilage-specific mitogen-inducible gene-6 knockout mice is independent of transforming growth factor-α

BACKGROUND/OBJECTIVE: Osteoarthritis (OA) is a whole joint disorder with no disease modifying treatment currently available. The Epidermal Growth Factor Receptor (EGFR) signaling pathway plays an important role in cartilage/bone development and its ligand transforming growth factor-α (TGFα) is upreg...

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Detalles Bibliográficos
Autores principales: Hadzic, Ermina, To, Bethia, Pest, Michael A., Qin, Ling, Beier, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400912/
https://www.ncbi.nlm.nih.gov/pubmed/37547183
http://dx.doi.org/10.1016/j.ocarto.2023.100387