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Molecular dynamics simulations reveal the hidden EF-hand of EF-SAM as a possible key thermal sensor for STIM1 activation by temperature
Intracellular calcium signaling is essential for many cellular processes, including store-operated Ca(2+) entry (SOCE), which is initiated by stromal interaction molecule 1 (STIM1) detecting endoplasmic reticulum (ER) Ca(2+) depletion. STIM1 is also activated by temperature independent of ER Ca(2+)...
Autores principales: | Neamtu, Andrei, Serban, Dragomir N., Barritt, Greg J., Isac, Dragos Lucian, Vasiliu, Tudor, Laaksonen, Aatto, Serban, Ionela Lacramioara |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400917/ https://www.ncbi.nlm.nih.gov/pubmed/37380078 http://dx.doi.org/10.1016/j.jbc.2023.104970 |
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