HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53

Cataract is a leading ocular disease causing global blindness. The mechanism of cataractogenesis has not been well defined. Here, we demonstrate that the heat shock protein 90β (HSP90β) plays a fundamental role in suppressing cataractogenesis. HSP90β is the most dominant HSP in normal lens, and its...

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Detalles Bibliográficos
Autores principales: Fu, Jia-Ling, Zheng, Shu-Yu, Wang, Yan, Hu, Xue-Bin, Xiao, Yuan, Wang, Jing-Miao, Zhang, Lan, Wang, Ling, Nie, Qian, Hou, Min, Bai, Yue-Yue, Gan, Yu-Wen, Liang, Xing-Miao, Xie, Liu-Liu, Li, David Wan-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400967/
https://www.ncbi.nlm.nih.gov/pubmed/37487085
http://dx.doi.org/10.1073/pnas.2221522120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400967/
https://www.ncbi.nlm.nih.gov/pubmed/37487085
http://dx.doi.org/10.1073/pnas.2221522120

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