ER chaperone GRP78/BiP translocates to the nucleus under stress and acts as a transcriptional regulator

Cancer cells are commonly subjected to endoplasmic reticulum (ER) stress. To gain survival advantage, cancer cells exploit the adaptive aspects of the unfolded protein response such as upregulation of the ER luminal chaperone GRP78. The finding that when overexpressed, GRP78 can escape to other cell...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Ze, Liu, Guanlin, Ha, Dat P., Wang, Justin, Xiong, Min, Lee, Amy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400976/
https://www.ncbi.nlm.nih.gov/pubmed/37487081
http://dx.doi.org/10.1073/pnas.2303448120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400976/
https://www.ncbi.nlm.nih.gov/pubmed/37487081
http://dx.doi.org/10.1073/pnas.2303448120

Ejemplares similares