An activator of voltage-gated K(+) channels Kv1.1 as a therapeutic candidate for episodic ataxia type 1

Loss-of-function mutations in the KCNA1(Kv1.1) gene cause episodic ataxia type 1 (EA1), a neurological disease characterized by cerebellar dysfunction, ataxic attacks, persistent myokymia with painful cramps in skeletal muscles, and epilepsy. Precision medicine for EA1 treatment is currently unfeasi...

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Detalles Bibliográficos
Autores principales: Servettini, Ilenio, Talani, Giuseppe, Megaro, Alfredo, Setzu, Maria Dolores, Biggio, Francesca, Briffa, Michelle, Guglielmi, Luca, Savalli, Nicoletta, Binda, Francesca, Delicata, Francis, Bru–Mercier, Gilles, Vassallo, Neville, Maglione, Vittorio, Cauchi, Ruben J., Di Pardo, Alba, Collu, Maria, Imbrici, Paola, Catacuzzeno, Luigi, D’Adamo, Maria Cristina, Olcese, Riccardo, Pessia, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401004/
https://www.ncbi.nlm.nih.gov/pubmed/37487086
http://dx.doi.org/10.1073/pnas.2207978120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401004/
https://www.ncbi.nlm.nih.gov/pubmed/37487086
http://dx.doi.org/10.1073/pnas.2207978120

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