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Fast protein folding is governed by memory-dependent friction

When described by a low-dimensional reaction coordinate, the folding rates of most proteins are determined by a subtle interplay between free-energy barriers, which separate folded and unfolded states, and friction. While it is commonplace to extract free-energy profiles from molecular trajectories,...

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Detalles Bibliográficos
Autores principales: Dalton, Benjamin A., Ayaz, Cihan, Kiefer, Henrik, Klimek, Anton, Tepper, Lucas, Netz, Roland R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401029/
https://www.ncbi.nlm.nih.gov/pubmed/37490533
http://dx.doi.org/10.1073/pnas.2220068120