Akebia saponin D acts via the PPAR‐gamma pathway to reprogramme a pro‐neurogenic microglia that can restore hippocampal neurogenesis in mice exposed to chronic mild stress

BACKGROUND: Using drugs to modulate microglial function may be an effective way to treat disorders, such as depression, that involve impaired neurogenesis. Akebia saponin D (ASD) can cross the blood–brain barrier and exert anti‐inflammatory and neuroprotective effects, so we wondered whether it migh...

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Detalles Bibliográficos
Autores principales: Zhang, Jinqiang, Liu, Qin, Su, Dapeng, Li, Liangyuan, Xiao, Chenghong, He, Hui, You, Zili, Zhou, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401137/
https://www.ncbi.nlm.nih.gov/pubmed/36987659
http://dx.doi.org/10.1111/cns.14196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401137/
https://www.ncbi.nlm.nih.gov/pubmed/36987659
http://dx.doi.org/10.1111/cns.14196

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