Cigarette smoke stimulates clonal expansion of Jak2(V617F) and Tet2(-/-) cells

INTRODUCTION: Somatic mutations in myeloid growth factor pathway genes, such as JAK2, and genes involved in epigenetic regulation, such as TET2, in hematopoietic stem cells (HSCs) leads to clonal hematopoiesis of indeterminate potential (CHIP) which presents a risk factor for hematologic malignancy...

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Detalles Bibliográficos
Autores principales: Ramanathan, Gajalakshmi, Chen, Jane H., Mehrotra, Nitya, Trieu, Tiffany, Huang, Aaron, Mas, Eduard, Monterrosa Mena, Jessica E., Bliss, Bishop, Herman, David A., Kleinman, Michael T., Fleischman, Angela G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401270/
https://www.ncbi.nlm.nih.gov/pubmed/37546389
http://dx.doi.org/10.3389/fonc.2023.1210528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401270/
https://www.ncbi.nlm.nih.gov/pubmed/37546389
http://dx.doi.org/10.3389/fonc.2023.1210528

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