RhoA/ROCK signalling activated by ARHGEF3 promotes muscle weakness via autophagy in dystrophic mdx mice

BACKGROUND: Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, leads to progressive and fatal muscle weakness through yet‐to‐be‐fully deciphered molecular perturbations. Emerging evidence implicates RhoA/Rho‐associated protein kinase (ROCK) signalling in DMD pathology, yet its direc...

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Detalles Bibliográficos
Autores principales: You, Jae‐Sung, Kim, Yongdeok, Lee, Soohyun, Bashir, Rashid, Chen, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401546/
https://www.ncbi.nlm.nih.gov/pubmed/37311604
http://dx.doi.org/10.1002/jcsm.13278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401546/
https://www.ncbi.nlm.nih.gov/pubmed/37311604
http://dx.doi.org/10.1002/jcsm.13278

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