ALS Variants of Annexin A11’s Proline-Rich Domain Impair Its S100A6-Mediated Fibril Dissolution

[Image: see text] Mutations in the proline-rich domain (PRD) of annexin A11 are linked to amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, and generate abundant neuronal A11 inclusions by an unknown mechanism. Here, we demonstrate that recombinant A11-PRD and its ALS-associate...

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Detalles Bibliográficos
Autores principales: Shihora, Aman, Elias, Ruben D., Hammond, John A., Ghirlando, Rodolfo, Deshmukh, Lalit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401653/
https://www.ncbi.nlm.nih.gov/pubmed/37433222
http://dx.doi.org/10.1021/acschemneuro.3c00169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401653/
https://www.ncbi.nlm.nih.gov/pubmed/37433222
http://dx.doi.org/10.1021/acschemneuro.3c00169

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