Design, synthesis, anti-proliferative evaluation, docking, and MD simulation studies of new thieno[2,3-d]pyrimidines targeting VEGFR-2

In this work, new thieno[2,3-d]pyrimidine-derived compounds possessing potential anticancer activities were designed and synthesized to target VEGFR-2. The thieno[2,3-d]pyrimidine derivatives were tested in vitro for their abilities to inhibit VEGFR-2 and to prevent cancer cell growth in two types o...

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Detalles Bibliográficos
Autores principales: El-Metwally, Souad A., Elkady, Hazem, Hagras, Mohamed, Husein, Dalal Z., Ibrahim, Ibrahim M., Taghour, Mohammed S., El-Mahdy, Hesham A., Ismail, Ahmed, Alsfouk, Bshra A., Elkaeed, Eslam B., Metwaly, Ahmed M., Eissa, Ibrahim H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401666/
https://www.ncbi.nlm.nih.gov/pubmed/37545598
http://dx.doi.org/10.1039/d3ra03128d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401666/
https://www.ncbi.nlm.nih.gov/pubmed/37545598
http://dx.doi.org/10.1039/d3ra03128d

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