Cargando…

Decoding the prognostic significance of integrator complex subunit 9 (INTS9) in glioma: links to TP53 mutations, E2F signaling, and inflammatory microenvironments

INTRODUCTION: Gliomas, a type of brain neoplasm, are prevalent and often fatal. Molecular diagnostics have improved understanding, but treatment options are limited. This study investigates the role of INTS9 in processing small nuclear RNA (snRNA), which is crucial to generating mature messenger RNA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Yu-Chieh, Chang, Pei-Chi, Hueng, Dueng-Yuan, Huang, Shih-Ming, Li, Yao-Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401760/ https://www.ncbi.nlm.nih.gov/pubmed/37537630 http://dx.doi.org/10.1186/s12935-023-03006-5

Ejemplares similares

Ancient ubiquitous protein 1 (AUP1) is a prognostic biomarker connected with TP53 mutation and the inflamed microenvironments in glioma
por: Chang, Pei-Chi, et al.
Publicado: (2023)

Deletions of 9p21 and TP53 in bladder cancer.
por: Park, W. S., et al.
Publicado: (1996)

Therapeutic Editing of the TP53 Gene: Is CRISPR/Cas9 an Option?
por: Mirgayazova, Regina, et al.
Publicado: (2020)

The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas
por: Cheng, Chiao-Pei, et al.
Publicado: (2016)

Clinical Significance and Systematic Expression Analysis of the Thyroid Receptor Interacting Protein 13 (TRIP13) as Human Gliomas Biomarker
por: Chen, Ssu-Han, et al.
Publicado: (2021)

Elephant TP53-RETROGENE 9 induces transcription-independent apoptosis at the mitochondria
por: Preston, Aidan J., et al.
Publicado: (2023)

The Anti-Cancer Effect of Four Curcumin Analogues on Human Glioma Cells
por: Luo, Siou-Min, et al.
Publicado: (2021)

Proteolipid Protein 2 Overexpression Indicates Aggressive Tumor Behavior and Adverse Prognosis in Human Gliomas
por: Chen, Yi-Hsuan, et al.
Publicado: (2018)

Prognostic significance of TP53 alterations in breast carcinoma.
por: Andersen, T. I., et al.
Publicado: (1993)

Integrator subunit 4 is a ‘Symplekin-like’ scaffold that associates with INTS9/11 to form the Integrator cleavage module
por: Albrecht, Todd R, et al.
Publicado: (2018)

Overexpression of PLOD3 promotes tumor progression and poor prognosis in gliomas
por: Tsai, Chia-Kuang, et al.
Publicado: (2018)

Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells
por: Liu, Tuoen, et al.
Publicado: (2017)

Significance of TP53 and immune-related genes to prostate cancer
por: Huang, Hang, et al.
Publicado: (2021)

Mitigating the Risk of t-MNs Development: TP53 or Not TP53?
por: Tesio, Melania
Publicado: (2023)

The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis
por: Leroy, Bernard, et al.
Publicado: (2013)

Prediction of TP53 mutations by p53 immunohistochemistry and their prognostic significance in gastric cancer
por: Hwang, Hye Jung, et al.
Publicado: (2020)

Differences in genetics and microenvironment of lung adenocarcinoma patients with or without TP53 mutation
por: Zeng, Dejun, et al.
Publicado: (2021)

Recurrent, truncating SOX9 mutations are associated with SOX9 overexpression, KRAS mutation, and TP53 wild type status in colorectal carcinoma
por: Javier, Breanna M., et al.
Publicado: (2016)

Low penetrance susceptibility to glioma is caused by the TP53 variant rs78378222
por: Enciso-Mora, V, et al.
Publicado: (2013)

Clinical Significance of TP53 Abnormalities in Newly Diagnosed Multiple Myeloma
por: Ye, Fang, et al.
Publicado: (2021)

Clinical significance of TP53 mutations in adult T‐cell leukemia/lymphoma
por: Sakamoto, Yuma, et al.
Publicado: (2021)

Clinical significance of p53 protein expression and TP53 variation status in colorectal cancer
por: Kim, Kyoung Min, et al.
Publicado: (2022)

Nrf2 Expressions Correlate with WHO Grades in Gliomas and Meningiomas
por: Tsai, Wen-Chiuan, et al.
Publicado: (2016)

Midkine expression in high grade gliomas: Correlation of this novel marker with proliferation and survival in human gliomas
por: Cheng, Yen-Po, et al.
Publicado: (2014)

miR-1269 promotes cell survival and proliferation by targeting tp53 and caspase-9 in lung cancer
por: Bao, Min, et al.
Publicado: (2018)

CRISPR/Cas9 treatment causes extended TP53-dependent cell cycle arrest in human cells
por: Geisinger, Jonathan M, et al.
Publicado: (2020)

TP53 and TP53-associated genes are correlated with the prognosis of paediatric neuroblastoma
por: Wang, Haiwei, et al.
Publicado: (2022)

Pro-Inflammatory Microenvironment Modulates the Transfer of Mutated TP53 Mediated by Tumor Exosomes
por: Domenis, Rossana, et al.
Publicado: (2021)

Shugoshin 2 is a biomarker for pathological grading and survival prediction in patients with gliomas
por: Kao, Ying, et al.
Publicado: (2021)

Prognostic significance of ARL9 and its methylation in low-grade glioma
por: Tan, Yutang, et al.
Publicado: (2020)

Osteopontin regulates human glioma cell invasiveness and tumor growth in mice
por: Jan, Hsun-Jin, et al.
Publicado: (2010)

ARID4B Knockdown Suppresses PI3K/AKT Signaling and Induces Apoptosis in Human Glioma Cells
por: Luo, Siou-Min, et al.
Publicado: (2021)

Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements
por: Trauernicht, Max, et al.
Publicado: (2023)

Significant Prognostic Features and Patterns of Somatic TP53 Mutations in Human Cancers
por: Zhang, Wensheng, et al.
Publicado: (2017)

Significance of TP53 mutation in bladder cancer disease progression and drug selection
por: Wu, Guang, et al.
Publicado: (2019)

Analysis of KRT1, KRT10, KRT19, TP53 and MMP9 expression in pediatric and adult cholesteatoma
por: Palkó, Enikő, et al.
Publicado: (2018)

Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma
por: Stolte, Björn, et al.
Publicado: (2018)

Immune Characteristics and Prognosis Analysis of the Proteasome 20S Subunit Beta 9 in Lower-Grade Gliomas
por: Liu, Junzhe, et al.
Publicado: (2022)

Decoding the dynamic tumor microenvironment
por: Clauset, Aaron, et al.
Publicado: (2021)

Antiproliferative and apoptotic effects of telmisartan in human glioma cells
por: Chang, Yung-Lung, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_j19slnb8hcf6it3jfchjq8nd94