Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapy

BACKGROUND: Platinum-drugs based chemotherapy in clinic increases the potency of tumor cells to produce M2 macrophages, thus leading to poor anti-metastatic activity and immunosuppression. Lysosome metabolism is critical for cancer cell migration and invasion, but how it promotes antitumor immunity...

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Detalles Bibliográficos
Autores principales: Ma, Jing, Ma, Ruijuan, Zeng, Xueke, Zhang, Liming, Liu, Jianing, Zhang, Wei, Li, Tao, Niu, Hanjing, Bao, Guochen, Wang, Chaojie, Wang, Peng George, Wang, Jiajia, Li, Xia, Zou, Taotao, Xie, Songqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401909/
https://www.ncbi.nlm.nih.gov/pubmed/37537587
http://dx.doi.org/10.1186/s13046-023-02768-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401909/
https://www.ncbi.nlm.nih.gov/pubmed/37537587
http://dx.doi.org/10.1186/s13046-023-02768-0

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