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Folding-upon-binding pathways of an intrinsically disordered protein from a deep Markov state model

A central challenge in the study of intrinsically disordered proteins is the characterization of the mechanisms by which they bind their physiological interaction partners. Here, we utilize a deep learning based Markov state modeling approach to characterize the folding-upon-binding pathways observe...

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Detalles Bibliográficos
Autores principales: Sisk, Thomas, Robustelli, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401938/
https://www.ncbi.nlm.nih.gov/pubmed/37546728
http://dx.doi.org/10.1101/2023.07.21.550103