Activation of the mevalonate pathway in response to anti-cancer treatments drives glioblastoma recurrences through activation of Rac-1

Glioblastoma is the deadliest adult brain cancer. Under the current standard of care almost all patients succumb to the disease and novel treatments are urgently needed. Dopamine receptor antagonists have been shown to target cancer cell plasticity in GBM and repurposing these FDA-approved drugs in...

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Detalles Bibliográficos
Autores principales: He, Ling, Ioannidis, Angeliki, Arambula, Evelyn, Hoffman, Carter J., Joshi, Purva, Kathiravan, Anoushka, Whitelegge, Julian, Liau, Linda M., Kornblum, Harley I., Pajonk, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402033/
https://www.ncbi.nlm.nih.gov/pubmed/37546917
http://dx.doi.org/10.1101/2023.07.23.550205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402033/
https://www.ncbi.nlm.nih.gov/pubmed/37546917
http://dx.doi.org/10.1101/2023.07.23.550205

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