Cargando…

Activation of the mevalonate pathway in response to anti-cancer treatments drives glioblastoma recurrences through activation of Rac-1

Glioblastoma is the deadliest adult brain cancer. Under the current standard of care almost all patients succumb to the disease and novel treatments are urgently needed. Dopamine receptor antagonists have been shown to target cancer cell plasticity in GBM and repurposing these FDA-approved drugs in...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Ling, Ioannidis, Angeliki, Arambula, Evelyn, Hoffman, Carter J., Joshi, Purva, Kathiravan, Anoushka, Whitelegge, Julian, Liau, Linda M., Kornblum, Harley I., Pajonk, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402033/ https://www.ncbi.nlm.nih.gov/pubmed/37546917 http://dx.doi.org/10.1101/2023.07.23.550205

Ejemplares similares

Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency
por: Henneman, L., et al.
Publicado: (2010)

Glucose restriction drives spatial reorganization of mevalonate metabolism
por: Rogers, Sean, et al.
Publicado: (2021)

12.2 Mevalonate kinase deficiency: Impaired isoprenoid synthesis induces IL-1beta production via activation of Rac1
por: Kuijk, LM, et al.
Publicado: (2008)

p53 regulates the mevalonate pathway in human glioblastoma multiforme
por: Laezza, C, et al.
Publicado: (2015)

Activation of the plant mevalonate pathway by extracellular ATP
por: Cho, Sung-Hwan, et al.
Publicado: (2022)

Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome
por: Haas, Dorothea, et al.
Publicado: (2006)

Activating Rac
por: Tuma, Rabiya S.
Publicado: (2006)

Cilia loss sensitizes cells to transformation by activating the mevalonate pathway
por: Deng, Yue-Zhen, et al.
Publicado: (2018)

Diagnostic value of urinary mevalonic acid excretion in mevalonate kinase deficiency (MKD)
por: Jeyaratnam, Jerold, et al.
Publicado: (2014)

Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms
por: Marei, Hadir, et al.
Publicado: (2016)

αvβ8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion
por: Reyes, Steve B., et al.
Publicado: (2013)

Identification of Differentially Expressed Proteins in Murine Embryonic and Postnatal Cortical Neural Progenitors
por: Shoemaker, Lorelei D., et al.
Publicado: (2010)

The mevalonate pathway in C. Elegans
por: Rauthan, Manish, et al.
Publicado: (2011)

Mevalonate Metabolism in Immuno-Oncology
por: Gruenbacher, Georg, et al.
Publicado: (2017)

Mevalonate kinase somatic mosaicism and bigenic genotypes may explain heterogeneity in mevalonate kinase deficiency
por: Shinar, Y, et al.
Publicado: (2015)

USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer
por: Maier, Carina R., et al.
Publicado: (2023)

Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma
por: Cui, Xiaoteng, et al.
Publicado: (2023)

Decorin expression is associated with predictive diffusion MR phenotypes of anti-VEGF efficacy in glioblastoma
por: Patel, Kunal S., et al.
Publicado: (2020)

Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer
por: Ricco, Natalia, et al.
Publicado: (2019)

Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells
por: Abdullah, Marwan Ibrahim, et al.
Publicado: (2017)

Identification of an Efficient Gene Expression Panel for Glioblastoma Classification
por: Crisman, Thomas J., et al.
Publicado: (2016)

Synthesis of Heterologous Mevalonic Acid Pathway Enzymes in Clostridium ljungdahlii for the Conversion of Fructose and of Syngas to Mevalonate and Isoprene
por: Diner, Bruce A., et al.
Publicado: (2017)

Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell–cell adhesion
por: Yamada, Soichiro, et al.
Publicado: (2007)

GEFs: Dual regulation of Rac1 signaling
por: Marei, Hadir, et al.
Publicado: (2016)

Beyond the Mevalonate Pathway: Control of Post-Prenylation Processing by Mutant p53
por: Borini Etichetti, Carla M, et al.
Publicado: (2020)

Genomic variations of the mevalonate pathway in porokeratosis
por: Zhang, Zhenghua, et al.
Publicado: (2015)

Tocilizumab for the Treatment of Mevalonate Kinase Deficiency
por: Rafiq, Nadia K., et al.
Publicado: (2018)

The Mevalonate Pathway Is Indispensable for Adipocyte Survival
por: Yeh, Yu-Sheng, et al.
Publicado: (2018)

Mevalonate kinase deficiency: current perspectives
por: Favier, Leslie A, et al.
Publicado: (2016)

Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation
por: Whalley, Helen J., et al.
Publicado: (2015)

OTEH-8. Pathway-based approach reveals sensitivity to radiation when targeting E2F1 in Glioblastoma
por: Alvarado, Alvaro, et al.
Publicado: (2021)

Diagnostic value of urinary mevalonic acid excretion in patietns with a clinical suspicion of mevalonate kinase deficiency (MKD)
por: Jeyaratnam, J, et al.
Publicado: (2015)

Crystal structure of mevalonate 3,5-bisphosphate decarboxylase reveals insight into the evolution of decarboxylases in the mevalonate metabolic pathways
por: Aoki, Mizuki, et al.
Publicado: (2022)

Mitogen-activated protein kinase mediates mevalonate-stimulated human mesangial cell proliferation
por: ZHOU, XIAOSHUANG, et al.
Publicado: (2015)

Mitochondrial respiratory chain dysfunction alters ER sterol sensing and mevalonate pathway activity
por: Wall, Christopher Tadhg James, et al.
Publicado: (2022)

Tumor necrosis factor receptor signaling modulates carcinogenesis in a mouse model of breast cancer
por: He, Ling, et al.
Publicado: (2020)

Rac and Rho driving tumor invasion: who's at the wheel?
por: Symons, Marc, et al.
Publicado: (2009)

Loss of dyskerin facilitates the acquisition of metastatic traits by altering the mevalonate pathway
por: Andrades, Evelyn, et al.
Publicado: (2023)

RAC Activity in Keloid Disease: Comparative Analysis of Fibroblasts from Margin of Keloid to its Surrounding Normal Skin
por: Witt, Erik, et al.
Publicado: (2008)

Interleukin-1 antagonists in Mevalonate Kinase Deficiency
por: Galeotti, C, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_vd0cdqvq62apknsfk3iv8a4v4f