Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions

Antibodies perform both neutralizing and non-neutralizing effector functions that protect against certain pathogen-induced diseases. A human antibody directed at the SARS-CoV-2 Spike N-terminal domain (NTD), DH1052, was recently shown to be non-neutralizing yet it protected mice and cynomolgus macaq...

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Detalles Bibliográficos
Autores principales: Pierre, Camille N., Adams, Lily E., Anasti, Kara, Goodman, Derrick, Stanfield-Oakley, Sherry, Powers, John M., Li, Dapeng, Rountree, Wes, Wang, Yunfei, Edwards, Robert J., Munir Alam, S., Ferrari, Guido, Tomaras, Georgia D., Haynes, Barton F., Baric, Ralph S., Saunders, Kevin O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402036/
https://www.ncbi.nlm.nih.gov/pubmed/37546738
http://dx.doi.org/10.1101/2023.07.25.550460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402036/
https://www.ncbi.nlm.nih.gov/pubmed/37546738
http://dx.doi.org/10.1101/2023.07.25.550460

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