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Transfer learning to leverage larger datasets for improved prediction of protein stability changes

Amino acid mutations that lower a protein’s thermodynamic stability are implicated in numerous diseases, and engineered proteins with enhanced stability are important in research and medicine. Computational methods for predicting how mutations perturb protein stability are therefore of great interes...

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Detalles Bibliográficos
Autores principales: Dieckhaus, Henry, Brocidiacono, Michael, Randolph, Nicholas, Kuhlman, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402116/
https://www.ncbi.nlm.nih.gov/pubmed/37547004
http://dx.doi.org/10.1101/2023.07.27.550881