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Application of monolayer graphene to cryo-electron microscopy grids for high-resolution structure determination

In cryogenic electron microscopy (cryo-EM), purified macromolecules are typically applied to a grid bearing a holey carbon foil, blotted to remove excess liquid and rapidly frozen in a roughly 20–100 nm thick layer of vitreous ice that is suspended across roughly 1 μm-wide foil holes. The resulting...

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Detalles Bibliográficos
Autores principales: Grassetti, Andrew V., May, Mira B., Davis, Joseph H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402136/
https://www.ncbi.nlm.nih.gov/pubmed/37546934
http://dx.doi.org/10.1101/2023.07.28.550908