Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy

The non-physiological nutrient levels found in traditional culture media have been shown to affect numerous aspects of cancer cell physiology, including how cells respond to certain therapeutic agents. Here, we comprehensively evaluated how physiological nutrient levels impact therapeutic response b...

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Detalles Bibliográficos
Autores principales: Rawat, Vipin, DeLear, Patrick, Prashanth, Prarthana, Ozgurses, Mete Emir, Tebeje, Anteneh, Burns, Philippa A., Conger, Kelly O., Solís, Christopher, Hasnain, Yasir, Novikova, Anna, Endress, Jennifer E., González-Sánchez, Paloma, Dong, Wentao, Stephanopoulos, Greg, DeNicola, Gina M., Harris, Isaac S., Sept, David, Mason, Frank M., Coloff, Jonathan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402161/
https://www.ncbi.nlm.nih.gov/pubmed/37546939
http://dx.doi.org/10.1101/2023.07.26.550731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402161/
https://www.ncbi.nlm.nih.gov/pubmed/37546939
http://dx.doi.org/10.1101/2023.07.26.550731

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