A CRISPR screen of HIV dependency factors reveals CCNT1 is non-essential in T cells but required for HIV-1 reactivation from latency

We sought to explore the hypothesis that host factors required for HIV-1 replication also play a role in latency reversal. Using a CRISPR gene library of putative HIV dependency factors, we performed a screen to identify genes required for latency reactivation. We identified several HIV-1 dependency...

Descripción completa

Detalles Bibliográficos
Autores principales: Hafer, Terry L, Felton, Abby, Delgado, Yennifer, Srinivasan, Harini, Emerman, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402164/
https://www.ncbi.nlm.nih.gov/pubmed/37546973
http://dx.doi.org/10.1101/2023.07.28.551016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402164/
https://www.ncbi.nlm.nih.gov/pubmed/37546973
http://dx.doi.org/10.1101/2023.07.28.551016

Ejemplares similares