Calibrated prediction intervals for polygenic scores across diverse contexts

Polygenic scores (PGS) have emerged as the tool of choice for genomic prediction in a wide range of fields from agriculture to personalized medicine. We analyze data from two large biobanks in the US (All of Us) and the UK (UK Biobank) to find widespread variability in PGS performance across context...

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Detalles Bibliográficos
Autores principales: Hou, Kangcheng, Xu, Ziqi, Ding, Yi, Harpak, Arbel, Pasaniuc, Bogdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402211/
https://www.ncbi.nlm.nih.gov/pubmed/37546999
http://dx.doi.org/10.1101/2023.07.24.23293056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402211/
https://www.ncbi.nlm.nih.gov/pubmed/37546999
http://dx.doi.org/10.1101/2023.07.24.23293056

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