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Notch Intracellular Domains form Transcriptionally Active Heterodimeric Complexes on Sequence-paired Sites

Notch signaling is universally conserved in metazoans where it is important for a wide variety of both normal and abnormal physiology. All four mammalian Notch receptors are activated by a conserved mechanism that releases Notch intracellular domains (NICDs) from the plasma membrane to translocate t...

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Detalles Bibliográficos
Autores principales: Gazdik, Tana R., Crow, Jacob J., Lawton, Tyler, Munroe, Chloe J., Theriault, Hannah, Wood, Travis M., Albig, Allan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402268/
https://www.ncbi.nlm.nih.gov/pubmed/37546896
http://dx.doi.org/10.21203/rs.3.rs-3147210/v1