SDPS-20 THE HER2 FLIP: HER2 AMPLIFICATION OF TUMOR CELLS IN THE CEREBROSPINAL FLUID (CSF-TCS) OF PATIENTS WITH LEPTOMENINGEAL METASTASIS HAVING SOLID TUMORS; IMPLICATIONS FOR TREATING THE LM TUMOR WITH ANTI-HER2 THERAPY

INTRODUCTION: Patients diagnosed with Leptomeningeal Metastasis (LM) have limited treatment options. However, they may benefit from targetable therapy. LM breast cancer patients with HER2 positive primary tumors treated with IT Trastuzumab experienced clinical benefit (Malani, 2020), and improved cr...

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Detalles Bibliográficos
Autores principales: Kumthekar, Priya, Youssef, Michael, Blondin, Nicholas, Azadi, Amir, Piccioni, David, Glantz, Michael, Carillo, Jose, Avgeropoulos, Nicholas, Makar, Sherif, Blouw, Barbara, Natasha, Anna, Fisher, Deanna, Huynh, Lan, Peters, John, Sweed, Nathan, Dugan, Michael, Kesari, Santosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Screening/Diagnostics/Prognostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402348/
http://dx.doi.org/10.1093/noajnl/vdad070.077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402348/
http://dx.doi.org/10.1093/noajnl/vdad070.077

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